Basic Information
Regular Relationship :
Tissue/Cell lineU87, U251 And Hek-293T
SpecieHomo sapiens (human)
CitationBiochim Biophys Acta Mol Basis Dis 2018 May 1864, 1783-1794 doi:10.1016/j.bbadis.2018.02.022 PMID:29501773
Reference title
PVT1 regulates the malignant behaviors of human glioma cells by targeting miR-190a-5p and miR-488-3p.
Experimental verification
qPCR,Luciferase reporter assay etc
Functional description
PVT1 was up-regulated in glioma specimens and cell lines.Knockdown of PVT1 impaired the malignant behaviors of glioma cells via the suppression of proliferation,migration and invasion,as well as through promotion of apoptosis.Furthermore,PVT1 was identified to affect the glioma cells via binding to miR-190a-5p and miR-488-3p,which were down-regulated and played tumor suppressor roles in glioma cells.Up-regulated miR-190a-5p or miR-488-3p partially rescued the suppressive effect induced by PVT1 knockdown.Myocyte enhancer factor 2C (MEF2C) was a direct downstream target of miR-190a-5p and miR-488-3p,which was proved to be an oncogene and involved in the PVT1 knockdown induced regulation of biological behaviors of glioma cells.Over-expression of MEF2C up-regulated JAGGED1 by increasing the promoter activity of JAGGED1.Over-expression of PVT1 promotes multiple drug-resistance in gastric cancer.
Annotations
External Annotation for PVT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
