Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1PWRN1[LncRNA]
miRNAmiR-425-5p[miRNA]
CeRNA2p53[mRNA]
Tissue/Cell lineHek-293,Ges-1,Mgc-803, Hgc-27, Sgc-7901, Mkn-45, Gc Tissues
SpecieHomo sapiens (human)
CitationClin Sci (Lond) 2018 May 23 132, 1003-1019 doi:10.1042/cs20171588 PMID:29535266
Reference title
Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of microRNA-425-5p.
Experimental verification
Microarray,qPCR,Western blot,RIP,Luciferase reporter assay
Functional description
PWRN1 affected PTEN/Akt/MDM2/p53 axis via suppressing miR-425-5p.PWRN1 up-regulated could reduce proliferation and metastasis and increased apoptosis in GC cells, while miR-425-5p had reverse effects. PWRN1 may target an oncogene miR-425-5p.
Annotations
External Annotation for PWRN1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
