Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1lincRNA-ROR[LncRNA]
miRNAmiR-145[miRNA]
CeRNA2KLF4[mRNA]
Tissue/Cell lineAgs1, Mgc803, Sgc7901, And Mkn48,Gastric Adenocarcinomas Tissues
SpecieHomo sapiens (human)
CitationOncotarget 2018 Apr 6 9, 18386-18399 doi:10.18632/oncotarget.24841 PMID:29719612
Reference title
Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer.
Experimental verification
qPCR,RNAi etc
Functional description
LINCROR could sponge the miR-148a, miR-145 and miR-21 and can act as ceRNA modulating the miRNA-mediated post-transcriptional regulation of EGFR, KLF4, DNMT1 and AGO4.The downregulation of LINCROR when its target miR-145 abundantly expressed.In addition,we observed the expression level LINCROR directly correlated with the overexpression of the miR-145.This relationship has been already reported in colon cancer and shown to be involved in overall survival.Our results suggest that reduced LINCROR/high miR-145 might be associated with better prognosis.LINCROR is an active member associated with reprogramming and stemness-related transcription factors.Downregulation of LINCROR by miR-145 might impair the cancer stemness by deregulation of another transcription factor KLF4.
Annotations
External Annotation for lincRNA-ROR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
