Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCervical Cancer
CeRNA1SNHG12[LncRNA]
miRNAmiR-424-5p[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineC33A, Me-180, Caski, Hela And Siha,Nc104
SpecieHomo sapiens (human)
CitationCell Physiol Biochem 2018 45, 2086-2094 doi:10.1159/000488045 PMID:29533945
Reference title
Upregulation of Long Non-Coding RNA Small Nucleolar RNA Host Gene 12 Contributes to Cell Growth and Invasion in Cervical Cancer by Acting as a Sponge for MiR-424-5p.
Experimental verification
qPCR,Luciferase reporter assay
Functional description
NHG12 was found to be abnormally elevated in human cervical cancer tissues compared with paired adjacent normal tissues.high SNHG12 expression in tumor tissues was significantly correlated with vascular involvement,lymph node metastasis,advanced FIGO stage and poor prognosis.the knockdown of SNHG12 was found to inhibit proliferation,migration and invasion of cervical cancer cells in vitro, and silencing SNHG12 was shown to suppress tumor growth in a nude mouse model. SNHG12 functioned as an endogenous sponge for miR-424-5p, thereby downregulating the expression of miR-424-5p in cervical cancer.the inhibition of miR-424-5p in SNHG12-depleted cells partially reversed the effects on cervical cancer cell apoptosis, adhesion and invasion.the tumor-promoting role of SNHG12 is to function as a molecular sponge, which negatively regulates miR-424-5p.
Annotations
External Annotation for SNHG12 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
