Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEndometrial Cancer
CeRNA1SNHG8[LncRNA]
miRNAmiR-152[miRNA]
CeRNA2c-Met[mRNA]
Tissue/Cell lineIshikawa,Japan, Hec1-A, Hec1-B, An3Ca, Rl95-2,Ec Tissue
SpecieHomo sapiens (human)
CitationEur Rev Med Pharmacol Sci 2018 Mar 22, 1629-1637 doi:10.26355/eurrev_201803_14698 PMID:29630089
Reference title
LncRNA SNHG8 participates in the development of endometrial carcinoma through regulating c-MET expression by miR-152
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
SNHG8 expression in endometrial carcinoma tissue was significantly higher than that in normal endometrium.After transfection with SNHG8 siRNA,the cell viability of AN3CA cells decreased, whereas the activity of Ishikawa was increased after transfection with SNHG8 overexpression plasmid.SNHG8 was bound to miR-152 and miR-152 targeted on c-MET. In addition, miR-152 mimics inhibited the expression of c-MET, and the inhibitory effect was reversed after SNHG8 overexpression. Silencing SNHG8 reduced c-MET expression, and c-MET expression was reversed after addition of miR-152 inhibitor.
Annotations
External Annotation for SNHG8 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
