Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1SPRY4-IT1[LncRNA]
miRNAmiR-101-3p[miRNA]
CeRNA2EZH2[mRNA]
Tissue/Cell lineLovo, Rko, Sw620 And Sw480
SpecieHomo sapiens (human)
CitationTumour Biol 2017 Jul 39, 1010428317716250 doi:10.1177/1010428317716250 PMID:28720069
Reference title
Long non-coding RNA SPRY4-IT1 promotes proliferation and invasion by acting as a ceRNA of miR-101-3p in colorectal cancer cells.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
SPRY4-IT1 was upregulated in human primary colorectal carcinoma tissues.Knockdown of SPRY4-IT1 inhibited colorectal carcinoma cell proliferation,migration,and invasion.Moreover,we confirmed that the expression of epithelial-mesenchymal transition-related genes was modulated through alteration of SPRY4-IT1 expression. SPRY4-IT1 could negatively regulate the expression of miR-101-3p in colorectal carcinoma cells.The bioinformatics prediction revealed putative miR-101-3p binding sites within SPRY4-IT1 transcripts.
Annotations
External Annotation for SPRY4-IT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
