Basic Information
Regular Relationship :
Tissue/Cell lineA549, H322, H460, Glc-82, Spc-A1,Lung Cancer Tumor Tissues
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2018 Mar 99, 9-17 doi:10.1016/j.biopha.2018.01.049 PMID:29324317
Reference title
TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown,RIP etc
Functional description
INCR overexpression suppressed proliferation and invasion in lung cancer cells.TINCR was confirmed as a molecular sponge of miR-544a. We further validated that miR-544a facilitated proliferation and invasion, and miR-544a could reverse TINCR-mediated anti-proliferation and anti-invasion effect in lung cancer cells. TINCR acted as a competing endogenous RNA (ceRNA) to sequester miR-544a from its target gene FBXW7. FBXW7 suppressed proliferation and invasion,and FBXW7 knockdown abolished the inhibition of TINCR on proliferation and invasion in lung cancer cells.
Annotations
External Annotation for TINCR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
