Basic Information
Regular Relationship :
Tissue/Cell lineControl And Bc Cell Lines
SpecieHomo sapiens (human)
CitationOncol Res 2018 Aug 23 26, 1083-1091 doi:10.3727/096504018x15152085755247 PMID:29321088
Reference title
Upregulation of long non-coding RNA TUG1 promotes bladder cancer cell 5 proliferation, migration and invasion by inhibiting miR-29c.
Experimental verification
qRT-PCR,Luciferase reporter assay,in vitro knockdown
Functional description
TUG1 was upregulated and microRNA-29c(miR-29c) was downregulated in BC tissues and cell lines.Furthermore, TUG1 knockdown markedly increased the expression of miR-29c in vitro.On the contrary, overexpression of TUG1 remarkably decreased the expression of miR-29c.Transfection with plasmids containing mutant TUG1 has no effect on the expression of miR-29c. There were direct interactions between miR-29c and the binding sites of TUG1.In addition,the inhibitory effects of small interfering RNA specific for TUG1 on BC cell proliferation,migration and invasion were reversed by downregulation of miR-29c.
Annotations
External Annotation for TUG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
