Basic Information
Regular Relationship :
Tissue/Cell lineShg44, U251, Gl15,U87,
SpecieHomo sapiens (human)
CitationOncol Res 2018 Dec 27 27, 107-115 doi:10.3727/096504018x15205622257163 PMID:29540255
Reference title
Long non-coding RNA TUNAR represses growth, migration and invasion of human glioma cells through regulating miR-200a and Rac1.
Experimental verification
qPCR,Western blot,luciferase reporter assay etc
Functional description
TUNAR was confirmed to positively regulate miR-200a,and knockdown of miR-200a reversed TUNAR-induced inhibitory effects on glioma cells. Further, Rac1 was negatively regulated by miR-200a.Rac1 overexpression abolished miR-200a overexpression-induced inhibition of viability,migration, and invasion, as well as increase of apoptosis.Besides,Rac1 knockdown inhibited glioma by inactivating the Wnt/β-catenin and NF-κB signal pathways.TUNAR played an anti-cancer role in glioma cells by upregulating miR-200a and inhibiting Rac1,thereby might represent a potential therapeutic target for the treatment of human glioma.
Annotations
External Annotation for TUNAR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
