Basic Information
Regular Relationship :
Tissue/Cell lineU87,Gbm Tissues
SpecieHomo sapiens (human)
CitationCancer Chemother Pharmacol 2018 Apr 81, 671-678 doi:10.1007/s00280-018-3522-y PMID:29397407
Reference title
Long non-coding RNA TUSC7 inhibits temozolomide resistance by targeting miR-10a in glioblastoma.
Experimental verification
qPCR,Western blot,in vitro knockdown etc
Functional description
Low expression of TUSC7 in GBM cells and tissues resistant to TMZ.Upregulation of TUSC7 suppressed both TMZ resistance and expression of multidrug resistance protein 1 (MDR1) in U87TR cells.TUSC7 acted by directly targeting and silencing expression of miR-10a gene,and miR-10a mediated TUSC7-induced inhibition on TMZ resistance in U87TR cells.
Annotations
External Annotation for TUSC7 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
