Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEsophageal Squamous Cancer
CeRNA1TUSC7[LncRNA]
miRNAmiR-224[miRNA]
CeRNA2AKT[mRNA]
Tissue/Cell lineTe-13, Kyse140, Ec9706, Kyse30,Het-1A,Escc Tissues
SpecieHomo sapiens (human)
CitationJ Exp Clin Cancer Res 2018 Mar 12 37, 56 doi:10.1186/s13046-018-0724-4 PMID:29530057
Reference title
LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1.
Experimental verification
qPCR,Western blot,RIP,luciferase reporter assays
Functional description
TUSC7 was downregulated in ESCC tissues and cells,and low TUSC7 indicated worse overall survival.TUSC7 specifically bound to miR-224, and we proved miR-224 was upregulated in ESCC and negatively correlated with TUSC7 expression.Overexpression of TUSC7/inhibition of miR-224 suppressed cell proliferation,colony formation and chemotherapy resistance of ESCC cells,and promoted cell apoptosis.TUSC7 suppressed the proliferation and chemotherapy resistance of ESCC cells by increasing DESC1 expression via inhibiting miR-224.TUSC7 suppressed chemotherapy resistance of ESCC by downregulating miR-224 to modulate DESC1/EGFR/AKT pathway.
Annotations
External Annotation for TUSC7 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
