Basic Information
Regular Relationship :
Tissue/Cell lineH520, Skmes1
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2018 Feb 5 496, 738-745 doi:10.1016/j.bbrc.2018.01.097 PMID:29355524
Reference title
Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown, RNAi
Functional description
UCA1 down-regulation inhibited cell proliferation and migration in both SKMES-1 and H520 lung cancer cells.Then we demonstrated that repressed UCA1 promoted the miR-193a expression and miR-193a could bind to the predicted binding site of UCA1. We then dissected the role of miR-193a in lung cancer and proved the anti-tumor role of miR-193a. Furthermore,miR-193a displayed its role in lung cancer via modulating the HMGB1 expression. In addition, over-expression of HMGB1 could restore the UCA1 knockdown induced repression of cell proliferation and migration.
Annotations
External Annotation for UCA1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
