Basic Information
Regular Relationship :
Tissue/Cell lineMhcc97,Mg63,Hfob1.19,Os-732 ,Neuroblastoma Tissues
SpecieHomo sapiens (human)
CitationOncol Res 2018 Dec 27 27, 55-64 doi:10.3727/096504018x15201143705855 PMID:29523218
Reference title
Knockdown of urothelial carcinoma associated 1 suppressed cell growth and migration through regulating miR-301a and CXCR4 in osteosarcoma MHCC97 cells.
Experimental verification
qPCR,Western blot,in vitro knockdown
Functional description
Knockdown of UCA1 reduced cell viability, inhibited migration and invasion, and promoted cell apoptosis.However,the effect of UCA1 knockdown on cell growth and migration was blocked by miR-301a overexpression,whose expression was regulated by UCA1. We also found that miR-301a positively regulated the CXCR4 expression. CXCR4 inhibition reversed the effect of miR-301a overexpression on cell growth and migration.Moreover,miR-301a activated the Wnt/-catenin and NF-B pathways via regulating CXCR4.
Annotations
External Annotation for UCA1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
