Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePancreatic Cancer
CeRNA1ZEB1[LncRNA]
miRNAmiR-205-5p[miRNA]
CeRNA2ADPGK-AS1[mRNA]
Tissue/Cell lineHek-293T, Panc-1 And Sw-1991
SpecieHomo sapiens (human)
CitationCancer Biol Ther 2018 Jul 3 19, 573-583 doi:10.1080/15384047.2018.1423912 PMID:29667486
Reference title
LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB2-mediated epithelial-mesenchymal transition.
Experimental verification
Microarray,qPCR,Western blot etc
Functional description
MiR-205-5p was low-expressed while ZEB1 and ADPGK-AS1 were high-expressed in PC tissues and cells compared with the normal.ADPGK-AS1 could directly target miR-205-5p and miR-205-5p could directly target ZEB1 3'UTR.The expression of MiR-205-5p was negatively correlated with proliferation,migration and invasion, and positively correlated with apoptosis rate of PC cells,while ZEB1 and ADPGK-AS1 had an inversed effect. Further in vitro and in vivo investigation indicated that epithelial-mesenchymal transition (EMT) could be restrained by miR-205-5p through targeting ZEB1.ADPGK-AS1 strongly promoted the tumorigenesis via downregulating miR-205-5p expression and induced the EMT process in vivo.ADPGK-AS1 inhibited miR-205-5p and therefore promoted PC progression through activating ZEB1-induced EMT.
Annotations
External Annotation for ZEB1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
