Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePancreatic Cancer
CeRNA1ZEB2-AS1[LncRNA]
miRNAmiR-204[miRNA]
CeRNA2HMGB1[mRNA]
Tissue/Cell lineAsPC-1, HPAC, Cfpac-1, and Panc-1
SpecieHomo sapiens (human)
CitationInt J Biol Macromol 2018 Sep 116, 545-551 doi:10.1016/j.ijbiomac.2018.05.044 PMID:29753015
Reference title
LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,RIP etc
Functional description
the expression level of ZEB2-AS1 was elevated in pancreatic cancer cell lines and tissues.ZEB2-AS1 inhibition decreased cell growth and invasion in pancreatic cancer.Mechanismly,ZEB2-AS1 exerted as a ceRNA and negatively regulated miR-204 expression.In addition, HMGB1 was identified as a down-stream target of miR-204. The miR-204/HMGB1 axis mediated ZEB2-AS1's effect on pancreatic cancer.lncRNA ZEB2-AS1 may be a candidate prognostic biomarker and a target for new therapies in pancreatic cancer patients.
Annotations
External Annotation for ZEB2-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
