Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGlioblastoma
CeRNA1AC023115.3[LncRNA]
miRNAmiR-26a[miRNA]
CeRNA2GSK3b-Mcl1[mRNA]
Tissue/Cell lineU87Mg And U251Mg
SpecieHomo sapiens (human)
CitationBiochim Biophys Acta Mol Cell Res 2017 Aug 1864, 1393-1404 doi:10.1016/j.bbamcr.2017.05.008 PMID:28499919
Reference title
Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy
Experimental verification
qPCR,westen blot,microarray etc.
Functional description
AC023115.3 was preferentially enriched in the Ago2-containing microRNA ribonucleoprotein complexes (miRNPs) compared with the immunoprecipitates with control IgG,indicating that AC023115.3 is present in the Ago2-containing miRNPs likely through an association with microRNAs.AC023115.3 was induced by cisplatin and suppressed glioma chemoresistance.AC023115.3 inhibited cisplatin-induced autophagy.AC023115.3 promoted cisplatin-induced apoptosis via decreasing autophagy. AC023115.3 acted as a miR-26a sponge and inhibited its activity.AC023115.3 sensitized glioma cell to cisplatin-induced apoptosis through regulation of the miR-26a-GSK3β-Mcl1 signalling.
Annotations
External Annotation for AC023115.3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
