Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1AF113014[LncRNA]
miRNAmiR-20a[miRNA]
CeRNA2Egr2[mRNA]
Tissue/Cell lineSmmc7721, Hepg2, Sk-Hep1 And Huh7
SpecieHomo sapiens (human)
CitationPLoS One 2017 12, e0177843 doi:10.1371/journal.pone.0177843 PMID:28542387
Reference title
LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells
Experimental verification
qPCR,Western blot etc.
Functional description
AF113014 is differentially expressed between HCC cell lines and normal hepatocytes.Furthermore,we discovered that AF113014 up-regulated Egr2 expression through interacting with miR-20a.
Annotations
External Annotation for AF113014 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
