Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1AF119895[LncRNA]
miRNAmiR-6508-3p[miRNA]
CeRNA2NXF3[mRNA]
Tissue/Cell lineL02 And Hcc Cell Lines
SpecieHomo sapiens (human)
CitationExp Cell Res 2018 Feb 1 363, 129-139 doi:10.1016/j.yexcr.2017.12.016 PMID:29274323
Reference title
AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p.
Experimental verification
Microarray,qRT-PCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
AF119895 promoted migration and invasion of HCC cells both in vitro and in vivo.Furthermore,we identified that NXF3 was a downstream target of AF119895.NXF3 depletion could decrease HCC cells migration and invasion.In addition,AF119895 could act as an endogenous sponge by binding to miR-6508-3p and reduce miR-6508-3p expression. And miR-6508-3p could regulate NXF3 by interacting with its 3'UTR.
Annotations
External Annotation for AF119895 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
