Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1ASLNC02525[LncRNA]
miRNAmiR-489-3p[miRNA]
CeRNA2TWIST1[mRNA]
Tissue/Cell lineHepg2, Qgy-7701, Smmc-7721,L-02
SpecieHomo sapiens (human)
CitationInt J Oncol 2017 Sep 51, 851-858 doi:10.3892/ijo.2017.4069 PMID:28713968
Reference title
Inhibition of proliferation and invasion of hepatocellular carcinoma cells by lncRNA-ASLNC02525 silencing and the mechanism.
Experimental verification
Luciferase reporter experiment,qPCR,etc.
Functional description
ASLNC02525, as an RNA sponge, broke the negative regulation of twist1 by hsa-miRNA-489-3p,and once ASLNC02525 was silenced,the highly expressed hsa-miRNA489-3p regained its regulation on twist1 and inhibited the proliferation and invasion.
Annotations
External Annotation for ASLNC02525 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
