Basic Information
Regular Relationship :
Tissue/Cell lineIhh-4, Tpc-1, K1, Hth83, Nthy-Ori 3-1
SpecieHomo sapiens (human)
CitationEur Rev Med Pharmacol Sci 2017 Jul 21, 3239-3246, PMID:28770959
Reference title
The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer.
Experimental verification
qPCR etc.
Functional description
ATB is upregulated in PTC tissues compared with noncancerous tissues.ATB is upregulated and functions as an oncogene in PTC.Furthermore, lncRNA-ATB may serve as a diagnostic biomarker and therapeutic target for PTC.High-expression of lncRNA-ATB is associated with large tumor size and lymph node metastasis.LncRNA-ATB has been reported to promote cancer metastasis via binding and negatively regulating miR-200 family,and then inducing epithelial-mesenchymal transition22.
Annotations
External Annotation for ATB |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
