Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieRetinoblastoma
CeRNA1sponge-183[Artifically engineered RNA]
miRNAmiR-183[miRNA]
CeRNA2Casp2[mRNA]
Tissue/Cell lineY79 Cells,Hek293
SpecieHomo sapiens (human)
CitationJ Biol Chem 2011 Sep 9 286, 31749-60 doi:10.1074/jbc.M111.259028 PMID:21768104
Reference title
Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina.
Experimental verification
qRT-PCR;luciferase reporter assays
Functional description
The miR-183/96/182 cluster sponge element was composed of 10 copies each of sequences complementary to miR-183, miR-96, and miR-182 with mismatches at positions 9–12 to enhance stability. This sequence was inserted into the 3'-UTR of EGFP in a pNOVA expression vector regulated by an Opsin promoter and ending with an SV40 polyadenylation signal
Annotations
External Annotation for sponge-183 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
