Basic Information
Regular Relationship :
Tissue/Cell lineA375, A875 And M14, And Human Epidermal Melanocytes
SpecieHomo sapiens (human)
CitationInt J Oncol 2017 Dec 51, 1941-1951 doi:10.3892/ijo.2017.4173 PMID:29075789
Reference title
BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR204.
Experimental verification
qPCR,Luciferase reporter assay,Western blot
Functional description
the expression of the BANCR was low in melanocytic nevus and human melanocytes but high in melanoma tissues and cell lines.Knockdown of BANCR inhibited melanoma cell proliferation and invasion,and induced cell apoptosis.the inhibitory effect of BANCR siRNA in cell growth and migration.miR204 was a direct target of BANCR and neurogenic locus notch homolog protein 2 (Notch2) was a direct target of miR204.BANCR may promote melanoma cell growth through inhibition of miR204,leading to the activation of Notch2 pathway. BANCR knockdown inhibited tumor growth in vivo.
Annotations
External Annotation for BANCR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
