Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1CASC2[LncRNA]
miRNAmiR-24-3p[miRNA]
CeRNA2SOX7[mRNA]
Tissue/Cell lineHepg2, Huh7
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2018 Aug 119, 6391-6397 doi:10.1002/jcb.26479 PMID:29091305
Reference title
LncRNA CASC2 inhibited the viability and induced the apoptosis of hepatocellular carcinoma cells through regulating miR-24-3p
Experimental verification
qPCR,Western blot etc.
Functional description
lncRNA CASC2,acting as an onco-suppressor, was involved in the pathogenesis and progression of HCC, and its possible mechanism was induced the growth inhibition on HCC through miR-24-3p/SOX7 axis.Our results revealed a possible regulatory mechanism in HCC pathogenesis and warranted that lncRNA CASC2 was an important regulator in HCC.
Annotations
External Annotation for CASC2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
