Basic Information
Regular Relationship :
Tissue/Cell lineSw480, Hct-116
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2017 Nov 95, 1644-1653 doi:10.1016/j.biopha.2017.09.052 PMID:28954383
Reference title
Long non-coding RNA CASC7 inhibits the proliferation and migration of colon cancer cells via inhibiting microRNA-21
Experimental verification
qPCR,Luciferase reporter assay,Western blot etc.
Functional description
CASC7 overexpression could inhibit cell viability, migration and invasion, and promote apoptosis in CRC cells.CASC7 and ING3 were both a target of miR-21 in CRC cells,and CASC7 could control ING3 expression by regulating miR-21.Moreover, we have found that CASC7 inhibited colon cancer cell proliferation and migration via miR- 21/ING3 axis.These observations suggested that CASC7 played an important role in CRC pathogenesis and may be considered as a novel diagnostic marker of CRC.
Annotations
External Annotation for CASC7 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
