Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieRetinoblastoma
CeRNA1CCAT1[LncRNA]
miRNAmiR-218-5p[miRNA]
CeRNA2CDC2[mRNA]
Tissue/Cell lineSo-Rb50, Y79 And Weri-Rb1
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2017 Mar 87, 683-691 doi:10.1016/j.biopha.2017.01.004 PMID:28088735
Reference title
Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p.
Experimental verification
qPCR,RNAi,Western blot,Cell migration and invasion assay etc.
Functional description
The expression of lncRNA CCAT1 in RB tissues was significantly increased compared with normal tissues. It was also shown that lncRNA CCAT1 in RB SORB50, Y79 and WERI-RB1 cells was significantly higher than that in normal podiatric retina. LncRNA CCAT1 promotes the proliferation migration and invasion, and reduces cell apoptosis of SO-RB50 and Y79 cells, probably through negative modulation of miR-218-5p.
Annotations
External Annotation for CCAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
