Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLaryngeal Squamous Cell Cancer
CeRNA1CCAT1[LncRNA]
miRNAmiR-218[miRNA]
CeRNA2ZFX[mRNA]
Tissue/Cell lineAmc-Hn-8 And Tu212
SpecieHomo sapiens (human)
CitationTumour Biol 2017 Jun 39, 1010428317699417 doi:10.1177/1010428317699417 PMID:28631575
Reference title
Long non-coding RNA CCAT1/miR-218/ZFX axis modulates the progression of laryngeal squamous cell cancer
Experimental verification
qPCR,western blot,Luciferase reporter assays etc.
Functional description
expressions of colon cancer–associated transcript-1 and zinc finger protein, X-linked were significantly higher while microRNA-218 expression was significantly lower in the laryngeal squamous cell cancer tissues than those in the adjacent normal tissues.Moreover, a novel CCAT1-miR-218-ZFX regulatory axis was demonstrated in the proliferation and invasion of LSCC cells in vitro and in vivo.
Annotations
External Annotation for CCAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
