Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1CCAT2[LncRNA]
miRNAmiR-34a[miRNA]
CeRNA2FOXM1[mRNA]
Tissue/Cell lineSmmc-7721, Plc/Prf/5, Huh7, Sk-Hep-1, And Hep3B
SpecieHomo sapiens (human)
CitationAm J Cancer Res 2017 7, 1423-1434, PMID:28744394
Reference title
A positive feedback loop of long noncoding RNA CCAT2 and FOXM0 promotes hepatocellular carcinoma growth.
Experimental verification
qPCR,Western blot,Luciferase report assay,RIP,ChIP etc.
Functional description
a significant upregulation of CCAT2 in HCC tissues as compared to non-tumor tissues.CCAT2 functions as a competitive endogenous RNA (ceRNA) of FOXM1 through competitive interaction with miR-34a. a positive correlation between the tumorous CCAT2 expression and a significantly reduced overall survival(OS).
Annotations
External Annotation for CCAT2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
