Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePancreatic Cancer
CeRNA1CRNDE[LncRNA]
miRNAmiR-384[miRNA]
CeRNA2IRS1[mRNA]
Tissue/Cell lineSw1990, Panc-1,Capan-1,Jf305 And Bxpc-3,Hpde6-C7,Hek293T
SpecieHomo sapiens (human)
CitationCell Prolif 2017 Dec 50 doi:10.1111/cpr.12389 PMID:28940804
Reference title
Long non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1.
Experimental verification
qPCR,Luciferase reporter assay,Western blot
Functional description
Upregulation of the expression of CRNDE was found in pancreatic cancer tissues as well as cell lines,in comparison with the adjacent non-tumour tissues and human pancreatic duct epithelial cells.High expression of CRNDE was correlated with poor clinicpathological characteristics and shorter overall survival.We identified miR-384 as a direct target for CRNDE.Moreover,the CRNDE knockdown considerably inhibited pancreatic cancer cell proliferation, migration and invasion not only in vitro but also in vivo.In addition, CRNDE positively regulated IRS1 expression through sponging miR-384.
Annotations
External Annotation for CRNDE |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
