Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1CRNDE[LncRNA]
miRNAmiR-136[miRNA]
CeRNA2E2F1[mRNA]
Tissue/Cell lineSw480, Hct116 And Ht-29
SpecieHomo sapiens (human)
CitationOnco Targets Ther 2017 10, 205-216 doi:10.2147/ott.S116178 PMID:28115855
Reference title
Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer.
Experimental verification
qPCR,RNAi,Western blot,RIP,Luciferase reporter assay,Cell migration and invasion assay etc.
Functional description
We confirmed the upregulation of CRNDE in both primary specimens from colorectal cancer patients and colorectal cancer cell lines.Overexpression of CRNDE promoted the migration and invasion potency of colorectal cancer cells. Knockdown of CRNDE with OXA treatment decreased cell viability and promoted DNA damage and cell apoptosis.Further in-depth mechanistic studies revealed that CRNDE functioned as a competing endogenous RNA for miR-136, led to the de-repression of its endogenous target,E2F transcription factor 1(E2F1).
Annotations
External Annotation for CRNDE |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
