Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1FBXL19-AS1[LncRNA]
miRNAmiR-203[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineLovo,Ht29,Hct116,Sw620
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2017 Jun 17 488, 67-73 doi:10.1016/j.bbrc.2017.05.008 PMID:28479250
Reference title
Long non-coding RNA FBXL19-AS1 plays oncogenic role in colorectal cancer by sponging miR-203
Experimental verification
microarray,qPCR,Luciferase reporter assay etc.
Functional description
FBXL19-AS1 was the most significantly upregulated lncRNA in metastatic tumors. Our results reveal the cancer-promoting effect of FBXL19-AS1, acting as a molecular sponge in negatively modulating miR-203, which might provide a new insight for understanding of CRC development.
Annotations
External Annotation for FBXL19-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
