Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOral Squamous Cell Cancer
CeRNA1FTH1P3[LncRNA]
miRNAmiR-224-5p[miRNA]
CeRNA2FZD5[mRNA]
Tissue/Cell lineScc1, Scc25, Tu183, Hsu3, Fadu, Oec-M1, Snu1041 Etc.
SpecieHomo sapiens (human)
CitationGene 2017 Apr 5 607, 47-55 doi:10.1016/j.gene.2017.01.009 PMID:28093311
Reference title
Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression.
Experimental verification
qPCR,Cell transfection,Western blot,Luciferase reporter assay,RNA pull-down assay etc.
Functional description
FTH1P3 was over-expressed in OSCC and decreased the survival rate of OSCC patients.Ectopic expression of FTH1P3 facilitates cell proliferation and colony formation in OSCC cells.Moreover, FTH1P3 acted as a ceRNA, effectively becoming sponge for miR-224-5p and thereby modulating the expression of fizzled 5. Importantly, expression analysis revealed that both FTH1P3 and fizzled 5 were up-regulated in OSCC cell lines and tissues, and over-expression of fizzled 5 also functioned as an oncogene in OSCC cells.
Annotations
External Annotation for FTH1P3 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
