Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieUveal Melanoma
CeRNA1FTH1P3[LncRNA]
miRNAmiR-224-5p[miRNA]
CeRNA2RAC1[mRNA]
Tissue/Cell lineOcm-1A, Mum-2C, C918, Mum-2B
SpecieHomo sapiens (human)
CitationPLoS One 2017 12, e0184746 doi:10.1371/journal.pone.0184746 PMID:29095823
Reference title
Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
Experimental verification
qPCR,Western blot etc.
Functional description
lncRNA FTH1P3 was commonly up-regulated in uveal melanoma cell lines and tissues and acted as an oncogene in uveal melanoma progression by inhibiting miR-224-5p expression. These results suggest that lncRNA FTH1P3 plays a crucial role in uveal melanoma and investigation of the underlying mechanism may be a target for the treatment of uveal melanoma.
Annotations
External Annotation for FTH1P3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
