Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePapillary Thyroid Cancer
CeRNA1GAS5[LncRNA]
miRNAmiR-222-3p[miRNA]
CeRNA2PTEN[mRNA]
Tissue/Cell lineBhp5-16, Tpc, K1 And Bhp2-7, Nthy-Ori 3-1
SpecieHomo sapiens (human)
CitationOncotarget 2018 Jan 9 9, 3519-3530 doi:10.18632/oncotarget.23336 PMID:29423063
Reference title
LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by sponging miR-222-3p in papillary thyroid carcinoma.
Experimental verification
qPCR,Luciferase reporter assay,Western blot
Functional description
Over-expression of Gas5 remarkably suppressed PTC cells proliferation in vitro and inhibited the growth of tumor cells in vivo likewise. Gas5 was identified as a target of miR-222-3p which was aberrantly high in PTC cells.Enhanced expression of miR-222-3p promoted the proliferation of PTC cells while knocking down miR-222-3p could inhibit it. The advanced effects of miR-222-3p on the proliferation of PTC cells could be partly reversed by the upregulation of Gas5 expression.Gas5 increased the protein level of the PTEN,one of miR-222-3p's targets, which further activated PTEN/AKT pathway.
Annotations
External Annotation for GAS5 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
