Basic Information
Regular Relationship :
Tissue/Cell lineThyroid Cancer tissues
SpecieHomo sapiens (human)
CitationExp Mol Pathol 2017 Aug 103, 71-77 doi:10.1016/j.yexmp.2017.06.004 PMID:28655518
Reference title
Effects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis.
Experimental verification
qPCR etc.
Functional description
TC patients with a lower 5-year survival rate showed upregulated levels of lncRNA H19 expression and,downregulated levels of miRNA let7a expression.This study aims to explore the effects of long non-coding RNA H19 (lncRNA H19) and microRNA let7a (miRNA let7a) expression on the prognosis of thyroid cancer.TC patients with a lower 5-year survival rate showed upregulated levels of lncRNA H19 expression and, downregulated levels of miRNA let7a expression.LncRNA H19 and miRNA let7a expression, tumor diameter,TNM stage and lymph node metastasis were independent prognostic factors of TC.increased lncRNA H19 and decreased miRNA let7a expression levels are associated with poor prognosis in TC patients.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
