Basic Information
Regular Relationship :
Tissue/Cell lineHct-116 And Sw-481
SpecieHomo sapiens (human)
CitationOncol Lett 2017 Aug 14, 2446-2452 doi:10.3892/ol.2017.6390 PMID:28781681
Reference title
Overexpression of long non-coding RNA H20 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells.
Experimental verification
qPCR,Western blot etc.
Functional description
overexpression of H20 is associated with decreased recurrence free survival and overall survival rates in patients with colorectal cancer,and increased viability and migration in colon cancer cells.H19 may function as a competing endogenous RNA for miR-138 and miR-200a,antagonizing their functions and thus leading to the derepression of their endogenous targets vimentin,zinc finger E-box-binding homeobox (ZEB) OL-9705-NPS 1 and ZEB2,all of which were associated with the EMT process.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
