Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1HCAL[LncRNA]
miRNAmiR-15a[miRNA]
CeRNA2LAPTM4B[mRNA]
Tissue/Cell lineLo2, Hepg2, Plc/Prf/5, Sk-Hep-1, Huh-7, And Smmc-7721
SpecieHomo sapiens (human)
CitationMol Ther Nucleic Acids 2017 Dec 15 9, 440-451 doi:10.1016/j.omtn.2017.10.018 PMID:29246322
Reference title
Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B.
Experimental verification
qPCR,Luciferase reporter assay,RIP
Functional description
HCAL that was highly expressed in HCC tissues.HCAL upregulation was clinically associated with poor differentiation, intravascular cancer embolus,and decreased survival of patients with HCC.HCAL silencing significantly inhibited the growth and metastasis of HCC cells both in vitro and in vivo.HCAL directly interacted with and functioned as a sponge for microRNAs such as miR-15a, miR-196a, and miR-196b to modulate LAPTM4B expression.the presence of a novel lncRNA-miRNA-mRNA regulatory network, the HCAL-miR-15a/miR-196a/miR-196b-LAPTM4B network,in HCC and indicate that HCAL may be a potential target for treating HCC.
Annotations
External Annotation for HCAL |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
