LncACTdb 3.0

miRNA

CeRNA2

VEGF[mRNA]

Tissue/Cell line

H1299, H23, H292, A549

Specie

Homo sapiens (human)

Citation

Oncol Res 2018 Jun 11 26, 725-734 doi:10.3727/096504017x15119467381615 PMID:29187267

Reference title

LncRNA-HOTAIR affects tumorigenesis and metastasis of non-small cell lung cancer by up-regulating miR-613

Experimental verification

qPCR,Western blot,Luciferase reporter assay etc.

Functional description

Down-regulation of HOTAIR suppressed tumorigenesis and metastasis of NSCLC via up-regulating the expression of miR-613.

External Annotation for HOTAIR
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)