Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1HOTAIR[LncRNA]
miRNAmiR-197[miRNA]
CeRNA2FUS1[mRNA]
Tissue/Cell lineHct116, Sw480, Lovo, Ht29, Fhc
SpecieHomo sapiens (human)
CitationOncol Res 2018 Apr 10 26, 473-481 doi:10.3727/096504017x15105708598531 PMID:29137688
Reference title
The long noncoding RNA HOTAIR promotes colorectal cancer progression by sponging miR-197
Experimental verification
qPCR,Luciferase reporter assay etc.
Functional description
HOTAIR knockdown promoted apoptosis and inhibited cell proliferation, migration and invasion in vitro and in vivo.Moreover, HOTAIR modulated the progression of colorectal cancer by competitively binding miR-197.Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role,and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of colorectal cancer.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
