Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1HOTAIR[LncRNA]
miRNAmiR-545[miRNA]
CeRNA2EGFR[mRNA]
Tissue/Cell lineSw480 And Lovo
SpecieHomo sapiens (human)
CitationMol Cell Biochem 2017 Jul 431, 45-54 doi:10.1007/s11010-017-2974-4 PMID:28364379
Reference title
MicroR-545 mediates colorectal cancer cells proliferation through up-regulating epidermal growth factor receptor expression in HOTAIR long non-coding RNA dependent.
Experimental verification
qPCR,Western blot,Luciferase report assay etc.
Functional description
HOTAIR expression was significantly up-regulated in colorectal tissues compared with normal tissues. miR-545 expression was suppressed by HOTAIR overexpression whereas enhanced by HOTAIR silence. Suppression of EGFR expression by miR-545 mimic was abrogated by HOTAIR overexpression. HOTAIR long non-coding RNA mediates microR-545 regulating colorectal cancer cells proliferation.Although therapeutic advantage has been raised in surgery with radiation and chemotherapy, patients still face a big challenge for improving the survival rate and quality of life.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
