Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1HOXD-AS1[LncRNA]
miRNAmiR-19a[miRNA]
CeRNA2ARHGAP11A[mRNA]
Tissue/Cell lineHcclm3, Mhcc97H, Mhcc97L, Smmc7721 And L02
SpecieHomo sapiens (human)
CitationMol Cancer 2017 Jul 19 16, 125 doi:10.1186/s12943-017-0676-x PMID:28724429
Reference title
The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc.
Functional description
remarkable overexpression of HOXD-AS1 in metastatic cancer tissues.In vitro and in vivo gain- or loss-of-function studies re-affirmed that HOXD-AS1 is able to facilitate cancer metastasis and inhibit apoptosis. HOXD-AS1 is an oncogenic lncRNA that promotes HCC metastasis and that its pro-metastatic phenotype can partially be attributed to the HOXD-AS1/miR19a/ARHGAP11A signaling axis. downregulated by ectopic HOXD-AS1 overexpression, leading to a remarkably reduced apoptotic effect. OXD-AS1 functions as a competing endogenous RNA (ceRNA) by “sponging� miR19a during HCC metastasis/recurrence.
Annotations
External Annotation for HOXD-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
