Basic Information
Regular Relationship :
Tissue/Cell lineMg63,Hfob1.19,Os-732
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2018 Jan 119, 1050-1061 doi:10.1002/jcb.26273 PMID:28688193
Reference title
Knockdown of lncRNA HULC inhibits proliferation, migration, invasion, and promotes apoptosis by sponging miR-122 in osteosarcoma.
Experimental verification
qPCR,Luciferase reporter assay,Western blot
Functional description
Suppression of HULC in osteosarcoma cells inhibited cell viability,migration,invasion, and promoted apoptosis. HULC functioned as an endogenous sponge for miR-122,and its silence functioned through upregulating miR-122.Furthermore,overexpression of miR-122 inactivated PI3K/AKT, JAK/STAT, and Notch pathways by downregulation of HNF4G.high levels of HULC were associated with low survival rates in osteosarcoma patients.
Annotations
External Annotation for HULC |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
