Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNeuronal Homeostasis
CeRNA1mir-92 sponge[Artifically engineered RNA]
miRNAmiR-92[miRNA]
CeRNA2KCC2[mRNA]
Tissue/Cell lineCerebellar Granule Neurons Cells
SpecieHomo sapiens (human)
CitationJ Neurochem 2010 May 113, 591-600 doi:10.1111/j.1471-4159.2009.06560.x PMID:20050974
Reference title
MicroRNA-92 modulates K(+) Cl( ) co-transporter KCC2 expression in cerebellar granule neurons
Experimental verification
Western blot;Northern blot;luciferase reporter assays
Functional description
Here we show that lentiviral-mediated microRNA-92 over-expression reduced KCC2 protein levels and positively shifted reversal potential of GABA induced Cl(-) currents in CGNs. In addition KCC2 re-expression reversed microRNA-92 electrophysiological phenotype. Consistently microRNA-92 inhibition induced both an increase of the level of KCC2and a negative shift in GABA reversal potential.
Annotations
External Annotation for mir-92 sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
