Basic Information
Regular Relationship :
Tissue/Cell lineAchn, Caki-1, Caki-2 And 786-O
SpecieHomo sapiens (human)
CitationAm J Cancer Res 2017 7, 312-322, PMID:28337379
Reference title
Long intergenic non-coding RNA 00152 promotes renal cell carcinoma progression by epigenetically suppressing P16 and negatively regulates miR-205.
Experimental verification
qPCR,RNAi,Western blot,RIP,ChIP,Luciferase reporter assay,Flow cytometry assay etc.
Functional description
LINC00152 expression was up-regulated in RCC tissues compared with adjacent normal tissues.Furthermore, knockdown of LINC00152 inhibited RCC cell proliferation and S phase cell proportion in vitro. Mechanistically,LINC00152 may contribute to RCC progression by epigenetically repressing P16 expression and interacted with miR-205.
Annotations
External Annotation for LINC00152 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
