Basic Information
Regular Relationship :
Tissue/Cell lineU87,U251,Glioma Tissues
SpecieHomo sapiens (human)
CitationMol Ther Nucleic Acids 2018 Mar 2 10, 170-186 doi:10.1016/j.omtn.2017.11.011 PMID:29499931
Reference title
Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
Knockdown of LINC00339 inhibited glioma cell proliferation, migration, invasion, and tube formation,meanwhile downregulating the expression of VM-related molecular MMP-2 and MMP-14.TWIST1 upregulated the promoter activities of MMP-2 and MMP-14.
Annotations
External Annotation for LINC00339 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
