Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNasopharyngeal Cancer
CeRNA1LINC00460[LncRNA]
miRNAmiR-149-5p[miRNA]
CeRNA2IL6[mRNA]
Tissue/Cell lineSune-1, Cne-1, Hne-1, Cne-2, C666-1 And Hone-1, Immortalized Nasopharyngeal Epithelial Cell Line
SpecieHomo sapiens (human)
CitationGene 2018 Jan 10 639, 77-84 doi:10.1016/j.gene.2017.10.006 PMID:28987345
Reference title
LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6.
Experimental verification
RNA-seq,qPCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
LINC00460 was markedly increased in NPC tissues and cells compared to their corresponding controls. Silencing LINC00460 was able to suppress NPC cell growth in vitro while overexpressing LINC00460 reversed this process. LINC00460 contributed to the progression of NPC through regulating miR-149-5p/IL6 signal pathway.
Annotations
External Annotation for LINC00460 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
