Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePancreatic Cancer
CeRNA1LINC00511[LncRNA]
miRNAmiR-29b-3p[miRNA]
CeRNA2VEGFA[mRNA]
Tissue/Cell linePanc-1, Mia Paca-2, Capan-2, Sw1990, Aspc-1, Bxpc-3
SpecieHomo sapiens (human)
CitationJ Cell Mol Med 2018 Jan 22, 655-667 doi:10.1111/jcmm.13351 PMID:28984028
Reference title
Linc00511 acts as a competing endogenous RNA to regulate VEGFA expression through sponging hsa-miR-29b-3p in pancreatic ductal adenocarcinoma.
Experimental verification
qPCR,Luciferase reporter assay,Western blot,RIP
Functional description
The aberrant up-regulation of linc00511 was detected in PDAC cell lines and patient specimens compared with controls.An increase in linc00511 expression indicates the adverse clinical pathological characteristics and poor prognosis. linc00511 depletion in PDAC cells decreased proliferation,migration, invasion and endothelial tube formation.linc00511 could up-regulate VEGFA via its competing endogenous RNA (ceRNA) activity on hsa-miR-29b-3p.
Annotations
External Annotation for LINC00511 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
