Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1LINC00657[LncRNA]
miRNAmiR-106a-5p[miRNA]
CeRNA2PTEN[mRNA]
Tissue/Cell lineHepg2, Huh7, Hep3B, Bel-7402, Smmc-7721, Hccm3
SpecieHomo sapiens (human)
CitationInt J Biochem Cell Biol 2017 Nov 92, 34-42 doi:10.1016/j.biocel.2017.09.008 PMID:28919047
Reference title
Long non-coding RNA 657 suppresses hepatocellular carcinoma cell growth by acting as a molecular sponge of miR-106a-5p to regulate PTEN expression
Experimental verification
qPCR,Western blot etc.
Functional description
The expression level of LINC00657 was downregulated in HCC tissues and HCC cell lines.Moreover,we illustrated the role of LINC00657 in suppressing the growth, invasion, migration of HCC in vitro.In addition, we found that LINC00657 can act as a ceRNA for PTEN mRNA through miR-106a-5p.Finally, we confirmed the role of LINC00657 in vivo.These results deepen our understanding of the role of LINC00657 in HCC.
Annotations
External Annotation for LINC00657 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
