Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1LINC00673[LncRNA]
miRNAmiR-150-5p[miRNA]
CeRNA2ZEB1[mRNA]
Tissue/Cell lineBeas-2B, A549, H1975, H596, H520, H1650, H1703 And Hek-293
SpecieHomo sapiens (human)
CitationMol Cancer 2017 Jul 11 16, 118 doi:10.1186/s12943-017-0685-9 PMID:28697764
Reference title
Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p.
Experimental verification
qPCR,Western blot etc.
Functional description
high linc00673 expression was associated with poor prognosis of NSCLC patients.Linc00673 acted as a ceRNA by sponging miR-150-5p and regulated ZEB1 expression indirectly. linc00673 modulated cell proliferation, migration, invasion and EMT by sponging miR-150-5p and regulating ZEB1 expression indirectly. the inhibition of linc00673 significantly attenuated the tumorigenesis ability of A549 cells in vivo. Linc00673 is associated with poor survival in NSCLC patients.
Annotations
External Annotation for LINC00673 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
