Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1LINC01296[LncRNA]
miRNAmiR-122[miRNA]
CeRNA2MMP-9[mRNA]
Tissue/Cell lineSgc-7901, Bgc-823, Mgc-803, And Mkn-45,Ges-1
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2018 Jan 97, 450-457 doi:10.1016/j.biopha.2017.10.066 PMID:29091895
Reference title
Long intergenic noncoding RNA 01296 aggravates gastric cancer cells progress through miR-122/MMP-9.
Experimental verification
qPCR,Western blot
Functional description
LINC01296 was up-regulated in GC tissue and correlated with poor prognosis.LINC01296 knockdown significantly inhibited GC tumor growth. LINC01296 sponged miR-122,LINC01296 was positively correlated with MMP-9 expression, while miR-122 was negatively correlated to it. Overall,results indicate that LINC01296 acts as oncogenic lncRNA in GC carcinogenesis, suggesting the LINC01296/miR-122/MMP-9 regulatory pathway in GC tumorigenesis.GC patients with high LINC01296 levels had poor overall survivals than that with low LINC01296 level.
Annotations
External Annotation for LINC01296 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
