Basic Information
Regular Relationship :
Tissue/Cell lineBgc823 And Sgc7901
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2017 Mar 11 484, 514-521 doi:10.1016/j.bbrc.2017.01.094 PMID:28115163
Reference title
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Experimental verification
qPCR,Cell transfection,Western blot,Luciferase reporter assay,Flow cytometry assay,Cell proliferation assay etc.
Functional description
lnc-ATB was significantly upregulated in GC tissues compared to lnc-ATB expression in ANTs.These high lnc-ATB expression levels predicted poor prognosis in GC patients. Low levels of lnc-ATB inhibited GC cell proliferation and cell cycle arrest in vitro. Lnc-ATB was found to directly bind miR-141-3p.Moreover, TGF-β actives lnc-ATB and TGF-β2 directly binds mir-141-3p.Finally, we demonstrated that lnc-ATB fulfilled its oncogenic roles in a ceRNA-mediated manner.
Annotations
External Annotation for ATB |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
